7^thInternational Conference on
Neurodegenerative Disorders & Stroke

Biography:

Z. Ismailov is a Medical Neurologist and doctor oriental medicine at Republic rehabilitation centre of diseases bone-movable system, Uzbekistan. 

Abstract:

Background. Currently telemedicine is actively developing, including mobile applications for patients. However, applications for patients with lesions of the lower extremities (RemEx - Reminder of exercises) have not yet been created, with the help of which patients can independently monitor their state of health and communicate with the attending physician remotely.

The purpose of the study is to develop and test in real clinical practice a mobile application for smartphones “RemEx”.

Material and methods. The mobile application “RemEx” has two components: the first is a mobile patient application directly, the second is a personal computer program used by a physician to monitor disease activity in patients. The patient part of “RemEx” includes filling out the questionnaires, monitoring the implementation of recommendations for therapeutic physical culture and medication. It is also possible to be in constant communication with a doctor through the mobile application. The testing of the mobile application was attended by patients from the Republic Children’s Rehabilitation center with diseases of bearing-movable system, which was created at the Department of Physiotherapy, neurorehabilitation, RChRC in 2018 by Z. Ismailov and is formed to the present.

Results. The average values of the RemEx index at the time of switching on and after 12 months of observation were 3.6±1.6 and 2.3±1.8 (p>0.5), in regimen of BRAI 1.5±1.2 and 1.4±1.1 respectively (p>0.5). It takes one minute for a doctor to analyze the state of health of 40 patients every day, with no notification of a deterioration in the health of patients. The decision in the case of receiving notification from the patient about the occurrence of a symptom or the development of an adverse reaction averages 6-10 minutes.

Conclusion. According to the study, we can conclude that the RemEx mobile application allows patients to independently monitor disease activity, store medical records and contact the doctor remotely. Continuous monitoring of the patient's condition allows you to maintain low disease activity or remission for a long time.

Biography:

Genc Struga is a Consultant Neurologist and Stroke in University Hospital Mother Tereza and attending Physician at Cerebrovascular Intensive Care Unit. He is an Experienced Consultant with a demonstrated history of working in the hospital & health care industry. Skilled in Clinical Research, Medical Education, Medicine, Neurology&Stroke, Neurosonology and Clinical Trials. Strong consulting professional with a Doctor of Philosophy (Ph.D.) focused in Neuroscience from University of Tirana Faculty of Medicine.

Abstract:

Background

The project aims to examine possible cognitive benefits of bilingualism in native speakers of Arvanitika, including the ability for further learning and acquisition of other languages. We aim to achieve statistically important number of Arvanites equal Bilingual and monolingual to be interview using a up to date questionnaire and TEA or TEA like cognitive screening

Method

This is a cross-sectional population study including bilingual and monolingual speakers without exclusion criteria and with respects to gender equality, stratified random sampling responders in the areas where Arvanite population traditionally lived achieving a sample number statistically important of responders in a population unofficially ranging from 200000-16000000 or 15% of population.

The samples are taken from areas where traditionally there are Arvanites with more than 500 villages in different province of Greece dominantly in Epirus,Follorina, Castoria Eubea , Attica, Corinth ,Boetia,Argolis ,Messenia,Acheae, Peloponnese ,Thraka , and settlements in Andros ,Hydra, Poros,Spetsai,Salamis Participants are voluntary ; they have the right to refuse participate and to withdraw their participation and data any time . To be eligible, potential participants have to be an old adult with no previous diagnosis of dementia, bilingual in Arvanitika and Greek or otherwise.

The method of the population surveys is personal in-home survey with in identified areas with significant population of Arvanites with Dr.Genc Struga and supervisor Co-Director of”Bilingualisem matters “ Dr.Thomas Bak in collaboration with“ Bilingualism matters “ Thessaloniki Team .The team will use their Greek colleagues connections and snowball sampling approach. This method is commonly used in social sciences when investigating hard-to-reach groups. Existing subjects are asked to nominate further subjects known to them, so the sample increases in size like a rolling snowball

Conclusions

Language characteristics such as phonosymbolisem and ethnography enhance the native neuroplasticity,making it easier for Albanian speaker to learn another language and to pronounce such new language with a more accurate accent. This factor is independent of CPH (critical period hypothesis) influencing L2 (second language) acquisition and with better pronunciation or accent.

Furthermore, to benefits of speaking native language, studies have confirmed that bilinguals performed significantly better than predicted from their baseline cognitive abilities, with strongest effects on general intelligence and reading.

Biography:

Genc Struga is a Consultant Neurologist and Stroke in University Hospital Mother Tereza and attending Physician at Cerebrovascular Intensive Care Unit. He is an Experienced Consultant with a demonstrated history of working in the hospital & health care industry. Skilled in Clinical Research, Medical Education, Medicine, Neurology&Stroke, Neurosonology and Clinical Trials. Strong consulting professional with a Doctor of Philosophy (Ph.D.) focused in Neuroscience from University of Tirana Faculty of Medicine.

Abstract:

NurAiD II contains 9 natural herbal extracts with proven effect to stimulate neuroplasticity and improve morbidity and cognition particularly in patients with ischemic stroke. The effect is in proliferation, differentiation and the migration of neuronal cells and the formation of new neuronal circuits affecting recovery of patients after stroke.

The activation by NeuroAid of the ATP-sensitive potassium channel located in the suffering neurons of the brain protects them from death. Indeed, the opening of the channel decreases the excitability of neurons (by hyperpolarization) preventing an overload of calcium and release of excitotoxic glutamate. Besides the beneficial effects in neuroplasticity already published, these results strengthen the interest of NeuroAid in stroke recovery.

NurAid II prevents necrosis and apoptotic cell death induced by global ischemia, enhances neurogenesis, and enhances functional recovery. This makes MLC901a potential novel therapeutic strategy in treating cognitive and neurological deficits caused by global ischemia from conditions that deprive the brain of oxygen and glucose, such as cardiac arrest.

Data from the Chinese MedicineNeuroaid Efficacy on Stroke recovery (CHIMES) study, an international, randomized, placebo-controlled, double-blind trial investigating the efficacy of MLC601 on stroke recovery in patients with ischemic stroke of intermediate severity in the preceding 72 hours showed improve long term morbidity and cognition. Functional independence defined as mRS ≤ 1 was significantly increased at 6 months and persisted up to 18 months after a stroke.

The results of the studies confirmed the overall benefit of NeuroAiD in stroke recovery and showed that treatment effect for achieving functional independence was greater among non-acute strokes, consistent with previous studies. In addition, the study showed that NeuroAiD had an excellent safety profile.

Biography:

Mai M Anwar is an Assistant Lecturer at the Future University of Egypt and National Organization for Drug Control and Research. She is also working as a Reviewer at Bioscience Reports journal, Biochemical Society (Neuroscience). She is trained and qualified to work on mesenchymal stem cells homing and developing techniques, PCR, Western blotting technique, Electrophoresis, ELISA, spectrophotometer, HPLC, dissolution and disintegration.

Abstract:

Background & Aim: Memory and learning disorders have been characterized by being a devastating long-term incurable diseases with a huge social and economic impact on worldwide society in addition to a diminished efficient available medical treatments with the potential for restoring and modifying memory defects onset and drawbacks. Deep brain stimulation via using neuroprotective inducers for restoring destructive degenerative brain structural diseases such as AD can be considered as being a promising successful therapy due to its various targets and underlying mechanisms for improving brain dysfunction by increasing synaptic plasticity and transmission. The main aim of this study is to suggest therapeutic medical protocol with a neuro regenerative potentials having the ability to restore normal brain mechanisms and mental functions in addition to understanding triggering pathways via which normal neurons diverse population restoration process can occur.

Method: Rats were divided randomly into nine groups, (G1) control group (G2) rats received lipopolysaccharide (LPS) injection (G3) LPS induced rats received NaHS, (G4) LPS induced rats received MSCs intracerebrally, (G5) LPS induced rats received MSCs+NaHS, (G6) LPS induced rats received kefir+Ginko Biloba (GB), (G7) LPS induced rats received MSCs+kefir+GB, (G8) LPS induced rats received NaHS+kefir+GB and (G9) LPS induced rats received MSCs+NaHS+kefir+GB.

Result: AD induction by LPS in rats resulted in downregulation of CBS and GSH brain tissue level accompanied with overexpression in amyloid β, MAPK, Tau, ACAT and MDA brain level in addition to elevated caspase-3 serum activity level

Conclusion: The administration of suggested medical protocol composed of MSCs and/or NaHS and/or kefir+GB resulted in relieving AD pathological deposited hallmarks with restoring the normal inflammatory brain excitatory levels by functioning as a potent neuro regenerative with the advantage of being easily implemented on human subjects as a result of its safety but with more clinical care obligations during conducting experimental design to minimize unpredictable drawbacks.